Round 4 group stage winners included Esperance, Horoya of Guinea, JS Saoura, and Simba who beat Al Ahly 1-0 in Dar es Salaam.
Returned in midweek with a 2-0 home defeat for Ole Gunnar Solskjaer's Manchester United against PSG.
Roma edged Porto 2-1 in the other Tuesday night fixture.
While on Wednesday the holders Real Madrid won 2-1 at Ajax and Tottenham scored an impressive three unanswered goals against Dortmund at Wembley.
Manchester City demolished Chelsea 6-0 at the Etihad to go back to the top of the EPL.
Argentine star Sergio Aguero netted a record-equaling treble against Sarri's hapless team.
Tottenham also won to maintain their title challenge.
The big derby game in Madrid finished in favour of Real who beat Atletico 3-1 at the Metropolitano.
Los Blancos are now the closest challengers to Barca, who drew 0-0 in Bilbao.
Second-placed Napoli were held goalless at Fiorentina on Saturday.
While Cristiano Ronaldo was on target for leaders Juve in their 3-0 defeat of Sassuolo.
PSG managed just a Cavani penalty in their single goal defeat of Bordeaux in the capital.
But that victory keeps them ten points clear of Lille and with two games in hand.
Leaders Borussia Dortmund let slip a three-goal lead at home to Hoffenheim and ended up drawing 3-3.
While champions Bayern Munich beat Schalke 3-1 at the Allianz Arena.
Leaders Porto drew 1-1 at Moreirense in the Friday night match.
While on Sunday Braga and Sporting won as did Benfica.
The Eagles certainly did good things for their goal difference after a 10-1 demolition of Nacional at the da Luz.
AFRICAN PLAYER NEWS & GOSSIP
Odion Ighalo (Nigeria) moves to Shanghai Shenhua.
Possibly moving to Everton - Yacine Brahimi (Algeria)
There were mixed results for the British clubs in the Europa League with Chelsea winning at Malmo but there were losses for Arsenal (in Borisov) and Celtic (at home to Valencia)
Inter, Sevilla, Napoli, Benfica, and Villarreal were among the other Round of 32 first leg winners.