Following the European playoff draw, a likely encounter is between Portugal and Italy and hence the elimination of one of those heavyweights.
The draw for the finals was made in Yaounde and it included a group matching the hosts, Cameroon, with Burkina Faso, Ethiopia, and Cape Verde.
The early stages of the new CAF Champions League and Confederations Cup continued.
Including wins for Mamelodi Sundowns, Esperance, Wydad Casablanca, and CR Belouizdad.
And also progression for JS Kabylie, Berkane, Enyimba, and Orlando Pirates.
After the fifth round of group matches, just five knockout places remain to be filled.
Among those confirming their participation in the last 16 were Manchester City, who edged Paris St-Germain thanks to a Gabriel Jesus winner at the Etihad, and Sporting, who eliminated Borussia Dortmund.
AC Milan, Atletico, Atalanta, and Barcelona will have to wait for matchday 6 before having a chance to qualify.
Ten teams now have confirmed places in the knockout round.
These include recent winners West Ham (at Rapid Wien), Lazio, Monaco, Bayer Leverkusen (who beat Celtic), Real Betis, Galatasaray, and Rangers, who eliminated Sparta Prague at Ibrox.
Among the eleven sides progressing into the knockout phase are Bodo/Glimt, Roma, Basel, LASK, Gent, AZ, Feyenoord, Rennes. and FC Copenhagen.
But not (yet) Antonio Conte's Tottenham who lost 2-1 at Mura in Slovenia.
The Saturday headlines featured very solid wins for Liverpool, 4-0 over Arsenal, and leaders Chelsea, 3-0 at Leicester.
Plus the demise of Ole Gunnar Solskjaer at Manchester United after the Red Devils went down 4-1 at Watford.
While on Sunday there were wins for Tottenham, 2-1 over Leeds, and second-placed Manchester City who seemed to have few issues beating Everton at the Etihad.
Real Madrid's 4-1 victory at ten-man Granada allowed them to go clear at the top of La Liga following Sociedad's home draw with Valencia.
On Saturday co-leaders AC Milan suffered a 4-3 defeat at Fiorentina (and hence lost their unbeaten record) but there were wins for Atalanta (in 4th) and Juventus (7th), at Lazio.
That was followed by the first loss for Napoli, after Spalletti's side went down 3-2 at the champions, Inter.
Ten-man PSG marched on, helped by goals from Mbappe and Lionel Messi, in beating Nantes 3-1 in the capital.
Nice, in second, won at Clermont but they remain a long way behind the Parisians.
And, sadly, the Lyon v Marseille clash was suspended after a few minutes due to crowd trouble.
The Friday night action featured a surprise 2-1 defeat for leaders Bayern Munich at Augsburg.
While Dortmund moved closer to the top after they beat Stuttgart by a single goal the following day.
But third-placed Freiburg suffered a home loss to Eintracht Frankfurt.
Benfica, Porto, Braga, and Sporting all progressed into the next round of the Portuguese Cup.
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