Tottenham survived a late VAR-denied goal by Manchester City to draw 2-2 at the Etihad.
And there were wins for Arsenal (home to Burnley) and well-travelled Liverpool (at Southampton)
But not Frank Lampard's Chelsea who were held to a 1-1 draw at Stamford Bridge by Leicester.
Champions Barcelona began the new campaign with defeat at San Mames after a brilliant late goal from Aritz Aduriz gave Athletic a 1-0 victory.
Their great rivals Real Madrid started with a 3-1 victory in Vigo with Karim Benzema on target for Los Blancos.
And Alvaro Morata scored the only goal (and missed a penalty) in Atletico's defeat of Getafe.
For many, it will be very hard to bet against a Ronaldo-inspired Juventus collecting the Scudetto again this season.
Serie A will begin on August 24th.
Memphis Depay and Moussa Dembele scored doubles in OL's 6-0 Friday night win over Angers.
But PSG found it harder at Rennes losing 2-1 at Roazhon Park.
Despite two strikes from Robert Lewandowski Bayern were held to a 2-2 draw by Hertha at the Allianz Arena.
But Borussia Dortmund had no such issues beating Augsburg 5-1 at the Signal Iduna on Saturday.
And another of the contenders, RB Leipzig, also began with a decisive victory - 4-0 at newcomers Union Berlin.
Benfica overcame local rivals Belenenses 2-0 while their challengers Porto included a Ze Luis treble in their 4-0 win over Setubal.
Sporting beat Braga to complete a trio of wins for the 'big three'.
AFRICAN PLAYER NEWS & GOSSIP
Lacina Traore (Ivory Coast) joins CFR Cluj, Chidozie Awaziem (Nigeria) joins Leganes on loan, Ngonda Muzinga (DR Congo) moves to Dijon, and Smouha in Egypt have signed Mohamed Koffi (Burkina Faso) and Mohamed Al Tarhouni (Libya)
Patrick Twumasi (Ghana) goes on loan to Gazisehir in Turkey, and Adlene Guedioura (Algeria) joins Al Gharafa in Qatar.
Hat-trick hero - Mbwana Samatta (Tanzania) netted three for Genk in Belgium.
And Luis Goncalves (Portugal) is the new coach of Mozambique.